Background This analysis provides the final results on cancer incidence in relation to oral
contraceptive (OC) use from the Oxford–Family Planning Association (Oxford-FPA)
contraceptive study, which closed at the end of 2010. An additional 6 years of observation
have been added since our last report and there has been an increase in the numbers of
cancers of over 50% at seven of the sites considered. Study Design The Oxford-FPA study
includes 17032 women aged 25–39 years recruited from 1968 to 1974 at contraceptive …

The Oxford–Family Planning Association (Oxford–FPA) contraceptive study has been
providing evidence of contraceptive risks and benefits for nearly 40 years and will be a study
with which most readers will be acquainted. This is the final report on cancer incidence from
this study. Over 17 000 subjects were initially recruited in the UK between 1968 and 1974
and were chosen mainly to look at oral contraceptive (OC) use. At the time, most OCs
contained 50 mg estrogen. The subjects at recruitment were made up of three groups: those …